Calendar

Mar
23
Thu
CBE Seminar- Huimin Zhao @ 130 Koffolt Laboratories, CBEC
Mar 23 @ 11:30 am – 12:30 pm

Seminar – Huimin Zhao

Thursday, March 23, 2017, 11:30 am
130 Koffolt Laboratories, CBEC
151 W. Woodruff Ave
Columbus, OH 43210
Mar
30
Thu
CBE Lowrie Lecture- Eric Kaler, University of Minnesota @ 130 Koffolt Laboratories, CBEC
Mar 30 @ 11:30 am – 12:30 pm

Lowrie Lecture I: Eric Kaler

President, University of Minnesota
Thursday, March 30, 2017, 11:30 am
130 Koffolt Laboratories, CBEC
151 W. Woodruff Ave
Columbus, OH 43210
Apr
6
Thu
CBE Seminar- Andrew Zydney, Penn State University @ 130 Koffolt Laboratories, CBEC
Apr 6 @ 11:30 am – 12:30 pm

Seminar – Andrew Zydney

Purification of DNA for Gene Therapy and Vaccines – New Opportunities for Membrane Technology
Thursday, April 6, 2017, 11:30 am
130 Koffolt Laboratories, CBEC
151 W. Woodruff Ave
Columbus, OH 43210

Andrew L. Zydney

Distinguished Professor

Chemical Engineering

The Pennsylvania State University

Purification of DNA for Gene Therapy and Vaccines – New Opportunities for Membrane Technology

 

Abstract

There is growing interest in using DNA for gene therapy and DNA-based vaccines.  Existing methods for DNA purification are inadequate for large-scale commercial production.  This talk examines the possibility of using membrane ultrafiltration for the purification of supercoiled plasmid DNA.  DNA transmission during ultrafiltration is a strong function of filtrate flux due to flow-induced elongation of the plasmid associated with the converging flow into the membrane pores.  Transmission of the open circular DNA was significantly less than that of the supercoiled plasmid, while transmission of the linear DNA was considerably enhanced due to differences in conformational flexibility.  New opportunities for enhancing DNA purification were identified using backpulsing to reduce fouling and using novel membranes with controlled pore morphology to pre-stretch the DNA in the elongation flow.  The results clearly demonstrate the potential of using membrane systems for commercial-scale purification of DNA.

Bio

Dr. Andrew L. Zydney is currently Distinguished Professor of Chemical Engineering at The Pennsylvania State University, having served as Head of that Department from 2004-2014.  Professor Zydney received his B.S. in Chemical Engineering from Yale in 1980 and his Ph.D. from M.I.T. in 1985.  He was a faculty member in the Chemical Engineering Department at the University of Delaware from 1985 – 2001.  Professor Zydney’s research is focused on membrane science and technology, with a particular emphasis on bioseparations and the purification of high value biological products.  He has published more than 200 articles on these topics, including invited contributions to the Encyclopedia of Bioprocess Technology and the Handbook of Biomedical Engineering.  He is the most recent recipient of the Excellence in Biological Engineering Publications Award from the AIChE.  Professor Zydney is the Editor-in-Chief of the Journal of Membrane Science, and he serves on the Editorial Boards for Separation and Purification Reviews, Separation Science and Technology, Current Opinion in Chemical Engineering, and Biotechnology and Bioengineering.  He served as President of the North American Membrane Society in 2002 – 2003, and was a member of the Board of Directors for 9 years.  He was elected a Fellow of the American Institute of Medical and Biological Engineers, the American Institute of Chemical Engineers, and the American Association for the Advancement of Science.  Dr. Zydney has received Excellence in Teaching Awards from the University of Delaware and the Penn State Engineering Alumni Society, and he is a past recipient of the Distinguished Teacher Award and the Outstanding Young Faculty Award from the American Society of Engineering Education.

Apr
20
Thu
CBE Seminar- Ramanan Krishnamoorti @ 130 Koffolt Laboratories, CBEC
Apr 20 @ 11:30 am – 12:30 pm

Seminar – Ramanan Krishnamoorti

Hybrid Nanoparticles: Structure, Dynamics and Properties
Thursday, April 20, 2017, 11:30 am
130 Koffolt Laboratories, CBEC
151 W. Woodruff Ave
Columbus, OH 43210

Ramanan Krishnamoorti

Interim Vice Chancellor/Vice President for Research and Technology Transfer

Chief Energy Officer

University of Houston

Hybrid Nanoparticles: Structure, Dynamics and Properties

 

Abstract

Polymer grafted nanoparticles are fascinating materials that bridge the gap between colloidal particles and star-polymers.  We have studied the structure and dynamics of highly grafted hybrid nanoparticles in the bulk and in dilute solutions and have elucidated the structure of the polymer chains and the arrangement of the nanoparticles as functions of polymer molecular weight and solvent quality.  Extending these to polymer blends wherein the matrix (unattached) chains is attracted to the grafted polymer chains has allowed us to determine the relationship between segment compatibility and polymer dewetting.  The consequences of the unique structure and dynamics of these grafted polymer chains on interfacial properties and as mobility control agents for enhanced oil recovery will be discussed in this talk.

Bio

Ramanan Krishnamoorti is the Interim vice chancellor/vice president for research and technology transfer and chief energy officer at the University of Houston.  He has served as chair of the UH Cullen College of Engineering’s chemical and biomolecular engineering department, associate dean of research for engineering, professor of chemical and biomolecular engineering with affiliated appointments as professor of petroleum engineering and professor of chemistry. Dr. Krishnamoorti obtained his bachelor’s degree in chemical engineering from the Indian Institute of Technology Madras and doctoral degree in chemical engineering from Princeton University in 1994.

Jun
15
Thu
The Department of Biomedical Engineering & the Department of Chemical & Biomolecular Engineering Present the Following Seminar: Bryan R. Smith, Ph.D @ L045 James
Jun 15 @ 11:00 am – 12:00 pm

The Department of Biomedical Engineering & the Department of Chemical & Biomolecular Engineering Present the Following Seminar:

Bryan R. Smith, PhD – Instructor, Dept of Radiology, Stanford University

Abstract:

Despite revolutionary developments in precision engineering of nanoparticles, nanomedicine successes in the clinic have been rare. This is mainly attributable to poor delivery to disease sites. I will describe my path to address these issues, starting briefly with non-invasive imaging approaches and computational simulations that uncover the complexity of nanoparticle targeting to cancer. I will discuss how nanoparticle imaging in living subjects led me to develop a novel ‘immune nanomedicine’ approach. Exploiting the native advantages of the immune system to deliver nanoparticle cargoes to disease sites, the power of this approach lies in its simplicity and reliability. It circumvents previous delivery issues by avoiding key biobarriers to nanoparticle transport, and could provide unprecedented flexibility in reliably targeting payloads to disease sites. I will illustrate the potential of this immune-based approach for multi-modal imaging diagnostics and/or therapeutics through an oncology imaging application, and will discuss how I intend to clinically translate nanomedicines.

 

Bio:

After receiving his Bachelor’s degree in Physics, Mathematics, and Biomedical Engineering at Tufts University, Bryan Smith completed his Ph.D. in Biomedical Engineering as an NSF IGERT Fellow at The Ohio State University working in cancer nanotechnology. He moved to Stanford University for his post-doctoral work, where he was awarded a Stanford Molecular Imaging Scholar NIH Fellowship as well as a Stanford Dean’s Fellowship. He was granted K99/R00 NIH Pathway to Independence and AACR (American Association of Cancer Research) awards for his work in cancer nanomedicine.

Sep
19
Tue
CBE Seminar: Belinda Hurley @ 130 Koffolt Lab
Sep 19 @ 11:30 am – 12:30 pm

Speaker: Belinda Hurley, Associate Professor, Research and Education, OSU Libraries

The OSU Libraries spend many millions each year to provide resources that are not freely available online. Belinda Hurley, OSU Libraries’ liaison for Physical Sciences and Engineering, will present an overview of available resources and services to those new to the OSU Libraries system.

Oct
5
Thu
CBE Seminar: Anna Balazs @ 130 Koffolt Lab
Oct 5 @ 11:30 am – 12:30 pm

Speaker: Anna Balazs, Distinguished Professor, Chemical and Petroleum Engineering

Affiliation: University of Pittsburg

Details TBD

Oct
10
Tue
Graduation Services Seminar @ 130 Koffolt Lab
Oct 10 @ 11:30 am – 12:30 pm

Speaker: Tim Watson, Director of Graduation Services

For graduate students approaching graduation: Come and learn about graduation requirements from the Graduate School.

Oct
26
Thu
CBE Seminar: Graduate Research Initiative Program @ 130 Koffolt Lab
Oct 26 @ 11:30 am – 12:30 pm

Details to come.

Nov
9
Thu
CBE Seminar: Alexander Katz @ 130 Koffolt Lab
Nov 9 @ 11:30 am – 12:30 pm

Speaker: Alexander Katz, Associate Professor of Chemical and Biomolecular Engineering

Affiliation: University of California-Berkeley

Details to come